The Organisation for Economic Cooperation and Development (OECD) has adopted a set of new and updated Test Guidelines for chemicals safety testing to keep pace with scientific progress for OECD members and Mutual Acceptance of Data adhering countries.

The new Test Guidelines are as follows.

  • TG 494 describes a new in vitro method for eye irritation hazard, by identifying chemicals not requiring classification for this hazard

  • TG 495 measures the phototoxicity of a chemical in vitro, through a reactive oxygen species assay

  • TG 248 measures the capacity of a chemical to activate or inhibit thyroid function in a frog eleutheroembryo

Meanwhile, the following TGs have also been updated.

  • The acute toxicity test guidelines for fish as described in TG 203.

  • The TG addressing the human health hazard endpoint skin sensitisation, following exposure to a test chemical, TG 442C.

  • The TG that describes an in vitro procedure allowing the identification of chemicals (substances and mixtures) not requiring classification and labelling for eye irritation or serious eye damage in accordance with UN GHSTG 492.

  • The test described in TG 431 that allows the identification of corrosive chemical substances and mixtures and it enables the identification of non-corrosive substances and mixtures when supported by a weight of evidence determination using other existing information.

  • TG 432 that describes a method to evaluate photo-cytotoxicity by the relative reduction in viability of cells exposed to the chemical in the presence versus absence of light. Balb/c 3T3 cells are maintained in culture for 24 h for formation of monolayers

  • TG 439 that describes an in vitro procedure that may be used for the hazard identification of irritant chemicals (substances and mixtures) in accordance with the UN Globally Harmonized System of Classification and Labelling (GHS) Category 2.

Last reviewed 4 July 2019