Last reviewed 14 November 2023

The Organisation for Economic Co-operation and Development’s (OECD’s) Environmental, Health and Safety (EHS) Programme has released a series of Adverse Outcome Pathway (AOP) documents to help improve knowledge of how chemicals induce adverse effects in humans and wildlife.

AOPs are the central element of a toxicological knowledge framework, built to support chemical risk assessment based on mechanistic reasoning.

The AOPs have been released following scientific review and OECD endorsement. It includes the following four single AOPs and a network of five AOPs addressing various toxicological and ecotoxicological pathways.

Some of these AOPs are considered of high regulatory relevance, as they are considered applicable to both human health and ecological risk assessments.